Archive for May, 2010

A new study of interest concerning psychopathy and Ventromedial Prefrontal Cortex, Economic decision-making in psychopathy: A comparison with ventromedial prefrontal lesion patients. By, Koenigs M, Kruepke M, Newman JP. Neuropsychologia. 2010 Jun;48(7):2198-2204. Here
“Psychopathy, which is characterized by a constellation of antisocial behavioral traits, may be subdivided on the basis of etiology: “primary” (low-anxious) psychopathy is viewed as a direct consequence of some core intrinsic deficit, whereas “secondary” (high-anxious) psychopathy is viewed as an indirect consequence of environmental factors or other psychopathology. Theories on the neurobiology of psychopathy have targeted dysfunction within ventromedial prefrontal cortex (vmPFC) as a putative mechanism, yet the relationship between vmPFC function and psychopathy subtype has not been fully explored. In this study, we administered two laboratory decision-making tasks (the Ultimatum Game and the Dictator Game) to a group of prisoners (n = 47) to determine whether the different subtypes of psychopathy (primary vs. secondary) are associated with characteristic patterns of economic decision-making, and furthermore, whether either subtype exhibits similar performance to patients with vmPFC lesions. Comparing primary psychopaths (n = 6) to secondary psychopaths (n = 6) and non-psychopaths (n = 22), we found that primary psychopathy was associated with significantly lower acceptance rates of unfair Ultimatum offers and lower offer amounts in the Dictator Game. Moreover, primary psychopaths were quantitatively similar to vmPFC lesion patients in their response patterns. These results support the purported connection between psychopathy and vmPFC dysfunction, bolster the distinction between primary and secondary psychopathy, and demonstrate the utility of laboratory economic decision-making tests in differentiating clinical subgroups.”

Related, a study from 2007 ;  The Role of Ventromedial Prefrontal Cortex in Decision Making: Judgment under Uncertainty or Judgment Per Se? By; Lesley K. Fellows and Martha J. Farah. Cerebral Cortex 2007 17(11):2669-2674.  Here  (where you also will find many other articles of interest.)

More on psychopathy and the reduced functioning in medial prefrontal cortex, The neural correlates of moral decision-making in psychopathy. By; AL Glenn, A Raine and RA Schug (2009)  Here

The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy. Blair (2008)  Here

The amygdala and ventromedial prefrontal cortex in morality and psychopathy. Blair (2007)  Here

Abnormal Ventromedial Prefrontal Cortex Function in Children With Psychopathic Traits During Reversal Learning. (May 2008)  Here

Damage to Ventromedial Prefrontal Cortex Impairs Judgment of Harmful Intent. By; Liane Young, Antoine Bechara, Daniel Tranel, Hanna Damasio, Marc Hauser and Antonio Damasio. Neuron 65, 1–7, March 25, 2010  Here

Write-up – Impaired judgment of harmful intent is linked with damage to prefrontal cortex (March 24, 2010)  Here

Also of interest;
An Underlying Cause for Psychopathic Behavior?  (Apr. 27, 2010)  Here
Psychopaths (sociopaths): White matter, unplugged (2009)   Here

On the subject of “decision-making” and harming others,  a video of interest   “What in the World are They Spraying?” – Official Trailer  Here   via Infowars Here and Chemtrails and Monsanto’s New Aluminum Resistance Gene – Coincidence?   Here

Last but not least, some book reviews by Dr. Fred Bortz;
Evil Genes: Why Rome Fell, Hitler Rose, Enron Failed, and My Sister Stole My Mother’s Boyfriend Here  ;   Cruelty: Human Evil and the Human Brain and Anatomy of Evil  Here
and some news from Dr. Simon, In Sheep’s Clothing: Understanding and Dealing with Manipulative People   Here


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